Gene variant linked with development of COPD in men
Researchers have linked a variant in the vitamin D receptor gene (VDR) with the onset of chronic obstructive pulmonary disease (COPD) in Caucasian men. The study population consisted of participants in...
View ArticleProtein drinks after exercise help maintain aging muscles
A new research report appearing online in the FASEB Journal shows that what someone drinks after exercise plays a critical role in maximizing the effects of exercise. Specifically, the report shows...
View ArticleWhat parasites eat is the key to better drug design
A new study has revealed in unprecedented detail how parasites use different nutrients needed for growth, providing University of Melbourne researchers with unique drug targets against Leishmania, a...
View ArticleMetabolic state of brain cancer stem cells significantly different than the...
The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those...
View ArticleResearchers discover a treatment against an aggressive childhood cancer
A study made by IDIBELL researchers shows that glucose metabolism inhibition with 2-deoxyglucose (2-DG) induces cell death in a type of childhood sarcoma: alveolar rhabdomyosarcoma. The results have...
View ArticleNovel therapeutic target identified to decrease triglycerides and increase...
Researchers at NYU Langone Medical Center today announce findings published in the October 20 issue of Nature that show for the first time the inhibition of both microRNA-33a and microRNA-33b...
View ArticleStudy identifies genetic basis of human metabolic individuality
In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes....
View ArticleVascular risk linked to long-term antiepileptic drug therapy
New research reveals that patients with epilepsy who were treated for extended periods with older generation antiepileptic drugs (AEDs) may be at increased risk for developing atherosclerosis, a common...
View ArticleTumor-specific pathway identified
A research team led by UT Southwestern Medical Center scientists has identified an atypical metabolic pathway unique to some tumors, possibly providing a future target for drugs that could reduce or...
View ArticleMitochondrial dysfunction present early in Alzheimer's, before memory loss
Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that...
View ArticleStudy shows how high-fat diets increase colon cancer risk
Epidemiologists have long warned that, in addition to causing obesity, eating too much fat and sugar puts a person at greater risk for colon cancer. Now, researchers at Temple University have...
View ArticleEpigenetics and epidemiology -- hip, hype and science
Epigenetics is the new hip science. Time Magazine's front cover and article, 'Why your DNA isn't your Destiny' from January 2010 explains why. Its more explicit subtitle provided the hook - 'The new...
View ArticleMutant Kras drives pancreatic cancer maintenance via metabolic pathways
A genetic mutation that drives the initiation of pancreatic cancer also manipulates metabolic pathways to support tumor growth and progression, scientists report in the journal Cell.
View ArticleAdvanced pancreatic tumors depend on continued oncogene activity
Researchers at Dana-Farber Cancer Institute have shown that advanced pancreatic cancers in mice can't survive without continued expression of a mutant oncogene that "rewires" key metabolic pathways to...
View ArticleA new candidate pathway for treating visceral obesity
Brown seems to be the color of choice when it comes to the types of fat cells in our bodies. Brown fat expends energy, while its counterpart, white fat stores it. The danger in white fat cells, along...
View ArticleDeveloping novel biomarkers to predict Alzheimer's disease
Scientists from VTT Technical Research Centre of Finland in collaboration with the University of Eastern Finland have recently discovered a serum biochemical signature which predicts progression to...
View ArticleComputational analysis identifies drugs to treat drug-resistant breast cancer
Researchers have used computational analysis to identify a new Achilles heel for the treatment of drug-resistant breast cancer. The results, which are published in Molecular Systems Biology, reveal...
View ArticleStudy reveals new molecular target for melanoma treatment
A laboratory study led by UNC medical oncologist Stergios Moschos, MD, demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in...
View ArticleResearchers identify novel metabolic programs driving aggressive brain tumors
Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
View ArticleGenetic variation may modify associations between low vitamin D levels and...
Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture,...
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